• Dr Axel Knebel, Managing Director and principal founder.

Publications (27 entries)

Hale B.G., Knebel A., Botting C.H., Galloway C.S., Precious B.L., Jackson D., Elliott R.M., Randall R.E. (2008) CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology in press.

Cuomo M.E., Knebel A., Morrice N., Paterson H., Cohen P., Mittnacht S. (2008) p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation. Nat Cell Biol. 10:723-30.

Wu W., Baxter J.E., Wattam S.L., Hayward D.G., Fardilha M., Knebel A., Ford E.M., da Cruz E Silva E., Fry A.M. (2007) Alternative splicing controls nuclear translocation of the cell cycle regulated Nek2 kinase. J. Biol. Chem. 282:26431-40.

Jaleel M, Nichols R.J., Deak M, Campbell D.G., Gillardon F., Knebel A. and Alessi D.R. (2007) LRRK2 phosphorylates moesin at Thr558; characterisation of how Parkinson's disease mutants affect kinase activity. Biochem. J. 405:307-317.

Peng C., Knebel A., Morrice N.A., Li X.J., Barringer K., Li J., Jakes S., Werneburg B., Wang L. (2007) Pim Kinase Substrate Identification and Specificity. Journal of Biochemistry 141:353-362

Cohen P. and Knebel A. (2006) KESTREL: a powerful method for identifying the physiological substrates of protein kinases (Review) Biochemal J. 393:1-6

Cuomo M.E., Knebel A., Platt G., Morrice N.A., Cohen P., Mittnacht S. (2005) Regulation of microfilament organization by KSHV- cyclin/ cdk phosphorylation of caldesmon. J. Biol. Chem. 280:35844-35858

Eyers CE, McNeill H, Knebel A, Morrice N, Arthur S, Cuenda A, Cohen P. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochemical J. 389:127-135

Cartlidge R., Knebel A., Peggie M., Alexandrov A., Phizicky E.M., Cohen P. (2005) The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. EMBO J. 24:1696-1705

Cole A., Knebel A., Morrice N.A., Robertson L.S., Irving A.J. Connolly C.N., Sutherland C. (2004) GSK-3 phosphorylation of the Alzheimers epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J. Biol. Chem. 279:50176-50180.

McNeill H., Knebel A., Arthur JS., Cuenda A., Cohen P. (2004) A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 384:391-400.

Knebel A. (2003) Protein kinases as drug targets, Sreening, Trends in Drug Discovery, Vol.4 pp 60-62 (Review)

Knebel A., Haydon C.E., Morrice N., Cohen P. (2002) Stress-induced regulation of eEF2 kinase by SB 203580-sensitive and insensitive pathways. Biochem J. 367:525-532.

Haydon C.E., Watt P.W., Morrice N., Knebel A., Gaestel M,. Cohen P. (2002) Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction. Arch. Biochem. Biophys.397, 224-231.

Knebel A., Morrice N, Cohen P. (2001) A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 20, 4360-4369.

Pre KESTREL publications

Knebel A., Böhmer F.D., Herrlich P. (2000) Radiation-induced signal transduction. Meth. of. Enzymol. 319:255-272 (Review).

Gross S., Knebel A., Tenev T., Neininger A., Gästel M., Herrlich P., Böhmer F.D. (1999) Inactivation of protein-tyrosine phosphatases as mechanism of UV-inducedsignal transduction. J. Biol. Chem. 274, 26378-26386

Herrlich P., Bender K., Knebel A., Böhmer F.D., Gross S., Blattner C., Rahmsdorf H.J., Gottlicher M. (1999) Radiation-induced signal transduction. Mechanisms and consequences. C. R. Acad Sci III. 322(2-3):121-125. (Review).

Hinterding K., Knebel A., Herrlich P., Waldmann H. (1998) Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors. Bioorg. Med. Chem. 6, 1153-1162

Herrlich A., Daub H., Knebel A., Herrlich P., Ullrich A., Schultz G., Gudermann T. (1998) Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc. Natl. Acad. Sci. U S A 95, 8985-8990

Waldmann, H., Hinterding, K., Herrlich, P., Rahmsdorf, H. J. and Knebel, A. (1997) Selective inhibition of receptor tyrosine kinases by synthetic analogues of aeroplysinin. Angew. Chem. Int. Ed. Engl., 36, 1541-1542.

Herrlich, P., Blattner, C., Knebel, A., Bender, K. and Rahmsdorf, H.J. (1997) Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants. Biol. Chem., 378, 1217-1229. (Review)

Bender, K., Blattner, C., Knebel, A., Iordanov, M., Herrlich, P. and Rahmsdorf, H. J. (1997) UV-induced signal transduction. J. Photochem. Photobiol. B, 37, 1-17. (Review)

Wilhelm, D., Bender, K., Knebel, A. and Angel, P. (1997) The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including p38 and JNK/SAPK kinases by alkylating agents. Mol. Cell. Biol., 17, 4792-4800.

Knebel, A., Rahmsdorf, H. J., Ullrich, A. and Herrlich, P. (1996) Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J., 15, 5314-5325.

Knebel, A., Iordanov, M., Rahmsdorf, H. J. and Herrlich, P. (1996) An oxidant sensor at the plasma membrane. Adv. Exp. Med. Biol., 387, 57-62.

Blattner, C., Knebel, A., Radler-Pohl, A., Sachsenmaier, C., Herrlich, P. and Rahmsdorf, H. J. (1994) DNA damaging agents and growth factors induce changes in the program of expressed gene products through common routes. Environ. Mol. Mutagenesis, 24, 3-10.