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Dr
Axel Knebel, Managing Director
Publications
(35 entries)
Zemla A., Thomas Y., Kedziora S., Knebel A., Wood N.T., Rabut G., Kurz T. (2013) CSN- and CAND-dependent remodelling of the budding yeast SCF complex. Nature Comm. in press
Strickson S., Campbell D. G., Emmerich C.H., Knebel A., Plater L., Ritorto M. S., Shpiro N., Cohen P. (2013) The anti-inflammatory drug BAY 11-7082 supresses the MYD88-dependent signaling network by targeting the ubiquitin system. Biochem. J. in press
Ohta A., Schumacher F.R., Mehellou Y., Johnson C., Knebel A., MacCartney T.J., Wood N.T., Alessi D.R., Kurz T. (2013) The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms; disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem. J. 451:111-122.
Lee D.W., Peggie M., Deak M., Toth R., Gage Z.O., Wood N., Schilde C., Kurz T., Knebel A. (2012)
The Dac-tag, an affinity tag based on penicillin binding protein 5. Analytical Biochemistry 428:64-72 .
Kondapalli C., Kazlauskaite A., Zhang N., Woodroof H., Campbell D., Gourlay R., Burchell L., Walden H., Macartney T.J., Deak M., Knebel A., Alessi D.R., Muqit M.M.K. (2012)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biology May 5: 120080 .
Bandau S., Knebel A., Gage Z.O., Wood N.T., Alexandru G. (2012)
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1a accumulation BMC Biol. 26:10-36.
Rabut G., Le Dez G., Verma R., Makhnevych T., Knebel A., Kurz T., Boone C., Deshaies R.J. Peter M. (2011)
The TFIIH subunit Tfb3 regulates cullin neddylation. Mol. Cell 43:488-495.
Tomlinson V., Gudmundsdottir K., Luong P., Leung K.Y., Knebel A., Basu S. (2010)
JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death Dis. 1:e29.
Hale
B.G., Knebel A., Botting C.H., Galloway C.S.,
Precious B.L., Jackson D., Elliott R.M., Randall R.E. (2008)
CDK/ERK-mediated phosphorylation of the human influenza A
virus NS1 protein at threonine-215. Virology 383:6-11.
Cuomo
M.E., Knebel A., Morrice N., Paterson H.,
Cohen P., Mittnacht S. (2008) p53-Driven apoptosis limits
centrosome amplification and genomic instability downstream
of NPM1 phosphorylation. Nat Cell Biol. 10:723-30.
Wu
W., Baxter J.E., Wattam S.L., Hayward D.G., Fardilha M., Knebel
A., Ford E.M., da Cruz E Silva E., Fry A.M. (2007)
Alternative splicing controls nuclear translocation of the
cell cycle regulated Nek2 kinase. J. Biol. Chem. 282:26431-40.
Jaleel
M, Nichols R.J., Deak M, Campbell D.G., Gillardon F., Knebel
A. and Alessi D.R. (2007) LRRK2 phosphorylates moesin
at Thr558; characterisation of how Parkinson's disease mutants
affect kinase activity. Biochem.
J. 405:307-317.
Peng
C., Knebel A., Morrice N.A., Li X.J., Barringer
K., Li J., Jakes S., Werneburg B., Wang L. (2007) Pim Kinase
Substrate Identification and Specificity. Journal
of Biochemistry 141:353-362
Cohen
P. and Knebel A. (2006) KESTREL: a powerful
method for identifying the physiological substrates of protein
kinases (Review) Biochemal
J. 393:1-6
Cuomo
M.E., Knebel A., Platt G., Morrice N.A.,
Cohen P., Mittnacht S. (2005) Regulation of microfilament
organization by KSHV- cyclin/ cdk phosphorylation of caldesmon.
J. Biol.
Chem. 280:35844-35858
Eyers
CE, McNeill H, Knebel A, Morrice N, Arthur
S, Cuenda A, Cohen P. (2005) The phosphorylation of CapZ-interacting
protein (CapZIP) by stress-activated protein kinases triggers
its dissociation from CapZ. Biochemical
J. 389:127-135
Cartlidge
R., Knebel A., Peggie M., Alexandrov A.,
Phizicky E.M., Cohen P. (2005) The tRNA methylase METTL1 is
phosphorylated and inactivated by PKB and RSK in vitro and
in cells. EMBO
J. 24:1696-1705
Cole
A., Knebel A., Morrice N.A., Robertson L.S.,
Irving A.J. Connolly C.N., Sutherland C. (2004) GSK-3 phosphorylation
of the Alzheimers epitope within collapsin response mediator
proteins regulates axon elongation in primary neurons. J.
Biol. Chem. 279:50176-50180.
McNeill
H., Knebel A., Arthur JS., Cuenda A., Cohen
P. (2004) A novel UBA and UBX domain protein that binds polyubiquitin
and VCP and is a substrate for SAPKs. Biochem J. 384:391-400.
Knebel
A. (2003) Protein kinases as drug targets, Sreening,
Trends in Drug Discovery, Vol.4 pp 60-62 (Review)
Knebel
A., Haydon C.E., Morrice N., Cohen P. (2002) Stress-induced
regulation of eEF2 kinase by SB 203580-sensitive and insensitive
pathways. Biochem J. 367:525-532.
Haydon C.E., Watt
P.W., Morrice N., Knebel A., Gaestel M,.
Cohen P. (2002) Identification of a phosphorylation site on
skeletal muscle myosin light chain kinase that becomes phosphorylated
during muscle contraction. Arch. Biochem. Biophys.397, 224-231.
Knebel
A., Morrice N, Cohen P. (2001) A novel method to
identify protein kinase substrates: eEF2 kinase is phosphorylated
and inhibited by SAPK4/p38delta. EMBO J. 20, 4360-4369.
Pre
KESTREL publications
Knebel
A., Böhmer F.D., Herrlich P. (2000) Radiation-induced
signal transduction. Meth. of. Enzymol. 319:255-272 (Review).
Gross
S., Knebel A., Tenev T., Neininger A., Gästel
M., Herrlich P., Böhmer F.D. (1999) Inactivation of protein-tyrosine
phosphatases as mechanism of UV-inducedsignal transduction.
J. Biol. Chem. 274, 26378-26386
Herrlich
P., Bender K., Knebel A., Böhmer F.D.,
Gross S., Blattner C., Rahmsdorf H.J., Gottlicher M. (1999)
Radiation-induced signal transduction. Mechanisms and consequences.
C. R. Acad Sci III. 322(2-3):121-125. (Review).
Hinterding K.,
Knebel A., Herrlich P., Waldmann H. (1998)
Synthesis and biological evaluation of aeroplysinin analogues:
a new class of receptor tyrosine kinase inhibitors. Bioorg.
Med. Chem. 6, 1153-1162
Herrlich A., Daub H., Knebel A., Herrlich
P., Ullrich A., Schultz G., Gudermann T. (1998) Ligand-independent
activation of platelet-derived growth factor receptor is a
necessary intermediate in lysophosphatidic, acid-stimulated
mitogenic activity in L cells. Proc. Natl. Acad. Sci. U S
A 95, 8985-8990
Waldmann,
H., Hinterding, K., Herrlich, P., Rahmsdorf, H. J. and Knebel,
A. (1997) Selective inhibition of receptor tyrosine
kinases by synthetic analogues of aeroplysinin. Angew. Chem.
Int. Ed. Engl., 36, 1541-1542.
Herrlich, P., Blattner, C., Knebel, A., Bender,
K. and Rahmsdorf, H.J. (1997) Nuclear and non-nuclear targets
of genotoxic agents in the induction of gene expression. Shared
principles in yeast, rodents, man and plants. Biol. Chem.,
378, 1217-1229. (Review)
Bender,
K., Blattner, C., Knebel, A., Iordanov, M.,
Herrlich, P. and Rahmsdorf, H. J. (1997) UV-induced signal
transduction. J. Photochem. Photobiol. B, 37, 1-17. (Review)
Wilhelm, D., Bender, K., Knebel, A. and Angel,
P. (1997) The level of intracellular glutathione is a key
regulator for the induction of stress-activated signal transduction
pathways including p38 and JNK/SAPK kinases by alkylating
agents. Mol. Cell. Biol., 17, 4792-4800.
Knebel,
A., Rahmsdorf, H. J., Ullrich, A. and Herrlich, P.
(1996) Dephosphorylation of receptor tyrosine kinases as target
of regulation by radiation, oxidants or alkylating agents.
EMBO J., 15, 5314-5325.
Knebel,
A., Iordanov, M., Rahmsdorf, H. J. and Herrlich,
P. (1996) An oxidant sensor at the plasma membrane. Adv. Exp.
Med. Biol., 387, 57-62.
Blattner,
C., Knebel, A., Radler-Pohl, A., Sachsenmaier,
C., Herrlich, P. and Rahmsdorf, H. J. (1994) DNA damaging
agents and growth factors induce changes in the program of
expressed gene products through common routes. Environ. Mol.
Mutagenesis, 24, 3-10.
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