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Substrates

 
Substrates of c-Akt = Protein Kinase B = PKB (40 entries)
Substrates Accession No Sites Reference
AHNAK  Q09666 (fragment) Ser5535 = Ser 1169 of Q09666 Sussmann et al., 2001 JCB 154:1019-1030
arfaptin 2 ADP ribosylation factor int. protein 2 NP_036534 Ser260 Rangone et al., 2005 JBC in press
ArgBP2gamma ? Ser232, Thr234, Thr379 Yuan et al., JBC 2005 in press
ARK5  NP_055655 Ser600 Suzuki et al.,2003 JBC 278:48-53
ASK1 = MAP3K5  NP_005914 Ser83 Kim et al., 2001 MCB 21:893-901
AS160  NP_055647 Ser588, Thr642 Kane et al., 2002 JBC 277:22115-22118
ATP citrate lyase  NP_001087 Ser455 Berwick et al., 2002 JBC 277:33895-33900
Bad Q92934 Ser75, Ser99

del Peso at al., 1997 Science 278:687-689
Datta et al., 1997 Cell 91:231-241
Caspase 9 alpha NP_001220 Ser196 Cardone et al., 1998 Science 282:1318-1321
CRHSP24     24kDa heat stable protein NP_690003 (rat) Ser52 Auld et al., Biochem J. 2005 in press
Ezrin, Cytovillin, Villin 2 NP_003370 Thr567 Shiue et al., 2004 JBC ahead of publication
Filamin C ( muscle specific actin BP 280) NP_001449 Ser2213 Murray et al., 2004 Biochem J. 384:489-94
Forkhead NP_002006 Thr24, Ser256, Ser319

Brunet et al., 1999 Cell 96:857-868
Rena et al., 1999 JBC 274:17179-17183
GABA (A) receptor* NP_068711 Ser410 Wang et al., 2003 Neuron 38:915-928
GSK3 alpha NP_063937 Ser19 Cross et al., 1995 Nature 378:785-789
GSK3 beta NP_002084 Ser9 Cross et al., 1995 Nature 378:785-789
HAND2, dHAND NP_068808 Ser114 ? Murakami et al., 2004 Eur J. Biochem 271:3330-9
HO-1 heme oxygenase 1 NP_002124 Ser188 Salinas et al., 2004 FEBS Lett. 578:90-94
Huntingtin NP_002102 Ser421 Humbert et al.,2002 Dev Cell 2:831-837
I kappa-B kinase alpha O15111 Thr23 Ozes et al., 1999 Nature 401:82-85
IRS-1 NP_005535 Ser270, Ser307, Ser330, Ser527 Paz et al., 1999 JBC:28816-28822
mTor P42345 Ser2448 Nave et al., 1999 Biochem. J. 344:427-431
PAK1 NP_002567 Ser21 Zhou et al., MCB 23:8058-8069
p21 WAF CDK inhibitor 1A NP_000380 Thr145, Ser 146 Li et al., 2002 JBC 277:11352-11361
p27Kip1 CDK inhibitor 1B P46527 Thr157 Shin et al., 2005 JBC 280:6055-6063
PIPPin RNA binding protein NP_055275 Ser58 Auld et al., 2005 Biochem. J. in press
PTP-1B protein tyrosine phosphatase 1B NP_002818 Ser50 Ravichandran et al.,2001 Mol. Endocrinol. 15:1768-1780
PFK-2* NP_006203 Ser466, Ser483 Deprez et al., 1997 JBC 272:17269-17275
PRAS40 NP_115751 Thr246 Kovacina et al., 2003 JBC 278:10189-10194
p47phox* NP_000256 Ser304, Ser328 Chen et al., 2003 J. Immunol. 170:5302-5308
14-3-3-zeta* PSHUAM Ser58 Powell et al., 2002 JBC 277:21639-21642
Raf-1 = c-Raf P04049 Ser259 Zimmermann and Moelling 1999 Science 286: 1741-1744
MKK4 = SEK1 NP_003001 Ser78 Park et al., 2002 JBC 277: 2573-2578
METTL1 tRNA methylase NP_005362 Ser27 Cartlidge et al., 2005 EMBO J. in press
Synip (only by AKT2 not by AKT1 or AKT3) NP_848604 Ser99 Yamada et al., 2005 J. Cell. Biol. 168:921-928
Tau   Thr212, Ser214 Ksiezak-Reding et al., 2003 BBA 1639:159-168
Tuberin = TSC2 = tuberous sclerosis 2 NP_066400 Ser939 Manning et al., 2002 Mol. Cell 10:151-161
WNK1 NP_061852 Thr60 Vitari et al., 2003 Biochem J. in press
YAP1 Yes ass. protein* P46937 Ser127 Basu et al.,2005 Mol. Cell.11:11-23
YB-1 Y-box binding protein 1* P67809 Ser102 Sutherland et al., 2005 Oncogene in press

* unusual phosphorylation site motiv

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