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Substrates

 

Substrates of CDK6 with cyclin D1 or viral cyclin
Substrates Accession No Sites Reference
Bcl-2 P10415 Ser70, Ser87 Ojala et al., 2000 Nat Cell Biol. 2:819-825
Caldesmon (in the presence of KSV-Cyclin) NP_149129 Thr730, Thr753, Ser759, Thr789 Cuomo et al., 2005 JBC in press
DMP1 NP_066968   Hirai et al., 1996 MCB 16:6457-6467
Histon H1     Godden-Kent et al., 1997 J. Virol. 71:4193-4198
88kDa substrate    

Kwon et al., 1995 Oncogene 11:2077-2083

Rb (Retinoblastoma) NP_000312 many Jung et al., 1994 MCB 14:7235-7244

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axel.knebel@kinasource.co.uk