Banner Kinasource protein kinase substrates for you

Home
About us
Services
News
Contact
Substrates

 

 

 
Substrates of Glycogen Synthase Kinase 3 = GSK3 (49 entries)
Substrates Sites Reference
amyloid precursor protein   Aplin et al., 1996 J. Neurochem. 67:699-707
APC   Ikeda et al., 2000 Oncogene 19:537-545
ATP-citrate lyase   Hughes et al., 1992 Biochem J. 288:309-314
Axin   Ikeda et al., 1998 EMBO J. 17:1371-1378
Axil   Yamamoto et al., 1998 MCB 18:2867-2875
BCL-3 C-terminus Viatour et al., 2004 Mol Cell 16:35-45
beta catenin   Ikeda et al., 1998 EMBO J. 17:1371-1378
c-Jun   Nikolakaki et al., 1993 Oncogene 8:833-840
Jun B   Nikolakaki et al., 1993 Oncogene 8:833-840
Jun D   Nikolakaki et al., 1993 Oncogene 8:833-840
Ci155   Jia et al., 2002 Nature 416:548-552
C/EBP alpha Thr222, Thr226 Ross et al., 1999 MCB 19:8433-8441
CRMP2 = DRP2     NP_001377 Thr 509, Thr514, S518 Cole et al., 2004 JBC ahead of publication
CRMP4 = DRP3     Q14195 Thr 509, Thr514, S518 Cole et al., 2004 JBC ahead of publication
CREB Ser129 Fiol et al., 1994 JBC 269:32187-32193
CTP   Cornell et al., 1995 Biochem. J. 310:699-708
Cyclin D1 Thr286 Diehl et al., 1998 Genes Dev. 12:3499-3511
Dystrophin c-terminus Michalak et al., 1996 Biochem. Cell. Biol. 74:431-437
eIF2B Ser535, Ser539

Welsh et al., 1998 FEBS Lett. 421:125-130
Wang et al., 2001, EMBO J. 20:4349-4359
Glycogen Synthase   Rylatt et al., 1980 Eur. J. Biochem. 107:529-537
Glucocorticoid receptor Thr171 Rogatzky et al., 1998 JBC 273:14315-14321
heat shock factor 1 Ser303 Chu et al., 1996 JBC 271:30847-30857
hnRNP D Ser83 Tolnay et al., 2002 Biochem. J. 363:127-136
K-casein   Donella-Deana et al., 1983 BBA 745:149-153
KRP = telokin   Krymsky et al., 2001 J. Muscle. Res. Cell. Motil. 22:425-437
MAB 1B   Jucas et al., 1998 J. Cell.Sci. 11:1351-1361
MAP 2 Thr 1620, Thr 1623 Yang et al., 1993 J. Protein Chem. 12:393-402
MAP 2C   Sanchez et al., 2000 Eur. J. Cell. Biol. 79:252-260
MITF Ser298 Takeda et al., 2000 Hum. Mol. Genet. 9:125-132
c-Myc Thr58, Thr62 Henrikson et al., 1993 Oncogene 8:3199-3209
L-Myc   Saksela et al., 1992 Oncogene 7:347-353
alpha NAC nascent polypeptide associated complex Thr159 Quelo et al., 2004 Biochemistry 43:2906-14
NCAM   Mackie et al., 1989 J. Neurosci. 9:1883-96
NDRG1        NP_006087 S342, S352, T362 Murray et al., 2004 Biochem. J. ahead of publication
NDRG2        NP_963834 Ser328 James Murray / Gillian Auld / Axel Knebel unpublished
neurofilament L   Guan et al., 1991 JBC 266:8262-8267
neurofilament M S502, S506, S603, S666 Guan et al., 1991 JBC 266:8262-8267
Yang et al., 1995 J. Neurochem. 64:1848-1854
neurofilament H Ser493 Guan et al., 1991 JBC 266:8262-8267
Sasaki et al., 2002 JBC 277:36032
Notch 1C   Foltz et al., 2002 Curr. Biol 12:1006-1011
p21 CIP1 Thr57 Rossig et al., 2002 JBC 277:6984-6989
p53 Ser33 Turenne & Price 2001 BMC Cell. Biol. 2:12
Presenilin = PS1 Ser397 Kirschenbaum et al., 2001 JBC 276:30701-30707
Pyruvate DH   Hoshi et al., 1996 PNAS USA 93:2719-2723
PP1 G-subunit AIFKPGFSPOPSRRGS Dent et al., 1989 FEBS Lett. 248:67-72
protein phosphatase inhibitor 2   Aitken et al., 1984 BBA:790:288-291
Stathmin   Moreno et al., 1998 Mol. Cell. Biochem. 183:201-209
Synphilin-1   Tanji et al., 2003 Neuropathology 23:199-202
RSK1 = p90RSK   Wang et al., 1995 BBRC 208:796-801
Tau Ser235, Ser404 Hanger et al., 1992 Neurosci Lett. 147:58-62
Yang et al., 1993 J. Neurochem. 61:1742-1747

 
axel.knebel@kinasource.co.uk