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Substrates

 

 

 

Substrates of PKC alpha (7 entries 29-07-2005)

Other PKC alpha substrates exist. We found specific evidence for the following.

Substrates Acc. No Sites Reference
Connexin-43 (CX43) = Gap junction alpha 1 protein P23242 Ser368 Doble et al., 2000 Circ. 86:293-301; Lampe et al., 2000 J. Cell. Biol.149:1503-1512
DGK-zeta = Diacylglycerol kinase zeta Q80UP3 Ser258, Ser265, Ser270, Ser271 Luo et al., 2003 JBC 278:39542-39547
histone H1 (standard in vitro substrate)      
HMGA1 = high mobility group AT-hook 1 AAH67083 Ser44, Ser64 Xiao et al., 2000 J. Neurochem. 74:392-399
IKK beta IkB kinase beta NP_001547 not fully mapped Lalena et al., 1999, MCB 19:2180-2188
NMDA receptor Q05586 Ser890, Ser896 Tingley et al., 1997 JBC 272:5157-5166
p47phox = Neutrophil cytosol factor 1 P14598 Ser303, Ser304, Ser315 and more Dang et al., 2001 J. Immunol.166:1206-1213

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axel.knebel@kinasource.co.uk