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Substrates

 

 

 

Substrates of PKC delta (14 entries 29-07-2005)

Other PKC delta substrates exist. Here we show pairs, where we found specific evidence.

Substrates Acc. No Sites Reference
14-3-3 beta P31946 Ser60 Hamaguchi et al., 2003 JBC 278:41557-41565
14-3-3 eta Q04917 Ser59 Hamaguchi et al., 2003 JBC 278:41557-41565
14-3-3 zeta P63104 Ser58 Hamaguchi et al., 2003 JBC 278:41557-41565
eEF-1 alpha NP_001393 Thr 432 Kielbassa et al., 1995 JBC270:6156-6162
EGF-receptor NP_005219
juxtamembrane domain
Davis and Czech 1985 PNAS USA 82:1974-1978 Downward et al., 1985 JBC 260:14538-14546
histone H1 (standard in vitro substrate)      
HMGA1 = high mobility group AT-hook 1 AAH67083 Ser44, Ser64 Xiao et al., 2000 J. Neurochem. 74:392-399
p300 CBP= E1A BP = p300 histone acetyltransferase/transcription coactivator Q09472 Ser89 Yuan et al., 2002 Biochim Biophys Acta. 1592:205-211
p47phox = Neutrophil cytosol factor 1 P14598 Ser303, Ser304, Ser315... Dang et al., 2001 J. Immunol.166:1206-1213
p73beta (tumor suppressor) AAK81885 Ser289 Ren et al., 2002 JBC 277:33758-33765
Phospholipid Scramblase = PLSCR1 NP_066928 Thr161 Frasch et al., 2000 JBC 275:23065-23073 ; Bailey et al., 2005 BBA 1733:199-209
SRBC sdr-related gene product that binds to c-kinase NP_659477 not mapped Izumi et al., 1997 JBC272:7381-7389
Stat3 = signal transducer and activator of transcription 3 NP_644805 Ser727 Jain et al., 1999 JBC 274:24392-24400
TNF receptor = TNF-R1 = CD120a P19438 not mapped Kilpatrick et al., 2000 Am. J. Physiol. Cell Physiol. 279: C2011–C2018

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axel.knebel@kinasource.co.uk