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Substrates

 

 

 
Substrates of PKC summary of all isoform substrates (89 entries 29-07-2005)
Substrates Acc. No Sites Reference
14-3-3 beta P31946 Ser60 Hamaguchi et al., 2003 JBC 278:41557-41565
14-3-3 eta Q04917 Ser59 Hamaguchi et al., 2003 JBC 278:41557-41565
14-3-3 zeta P63104 Ser58 Hamaguchi et al., 2003 JBC 278:41557-41565
Adenylate Cyclase type V   not mapped Kawabe et al., 1994 JBC 269:16554-16558
Angiotensin II receptor = AT(1A) NP_000676 Ser331, Ser338, Ser348 Qian et al., 1999 Biochem. J. 1999 343 Pt 3:637-644
Arrestin   not mapped Sagi-Eisenberg et al., 1989 Cell Signal. 1:519-531
B-50 = GAP43 = Neuromodulin P55860 Ser41 De Graan et al., 1988 J. Recept. Res 8:345-361, Coggins and Zwiers 1989 J. Neurochem. 53:1895-1901
calbindin-D28K P05937 not mapped Gagnon and Welsh 1997 Biochem Cell Biol. 75:33-40
CaM binding protein Adducin P35611 Ser716, Ser726 Waseem et al., 1988 Eur J Biochem. 178:563-573
CD3 gamma subunit of T-cell receptor P09693 Ser145, Ser148 Davies et al., 1987 JBC 262:10918-10921
CD34 antigen NP_001764 not mapped Fackler et al., 1990 JBC 265:11056-11061
CDK7 = CAK = CDK activating kinase NP_001790 not mapped Acevedo-Duncan et al., 2002 Cell Prolif. 35:23-36
Centaurin alpha 1 O75689 Ser87, Thr276 Zemlickova et al., 2003 BBRC 307:459-465
cGMP phospho diesterase PDE alpha P16499 not mapped Udovichenko et al., 1993 Biochem. J. 295:49-55
cGMP phospho diesterase PDE gamma P18545 not mapped Udovichenko et al., 1993 Biochem. J. 295:49-55
Connexin-43 (CX43) = Gap junction alpha 1 protein P23242 Ser368 Doble et al., 2000 Circ. 86:293-301; Lampe et al., 2000 J. Cell. Biol.149:1503-1512
CPI-17 = PKC potentiated inhibitor of 17kDa O18734 Thr38 Zemlickova et al., 2004 BBRC 316:39-47
CTFR, cystic fibrosis transmembrane conductance regulator Cl- channel P13569 not mapped Berger et al., 1993 JBC 268:2037-2047
Cytohesin 2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor) Q99418 Ser392 Frank et al., 1998 MCB 9:3133-3146
Deoxyhypusine Synthase P49366 not mapped Kang et al., 2002 Exp. Mol. Med. 34:489-495
DGK-zeta = Diacylglycerol kinase zeta Q80UP3 Ser258, Ser265, Ser270, Ser271 Luo et al., 2003 JBC 278:39542-39547
DNA topoisomerase I P11387 not mapped Samuels et al., 1989 FEBS Lett. 259:57-60
EBP-50 = Ezrin-Radixin-Moesin (ERM) binding phosphoprotein 50 O14745 Ser337, Ser338 Fouassier et al., 2005 Exp. Cell Res. 306:264-273
eEF-1 alpha NP_001393 Thr 432 Kielbassa et al., 1995 JBC270:6156-6162
EGF-receptor NP_005219
juxtamembrane domain		 Davis and Czech 1985 PNAS USA 82:1974-1978 Downward et al., 1985 JBC 260:14538-14546
ErbB2 = Neu NP_004439 juxtamembrane domain Dobashi et al., 1989 DNA 8:723-732
GluR2 P42262 Ser880 Matsuda et al., 1999 J. Neurochem. 73:1765-1768
GluR4 NP_000820 Ser862 Carvalho et al., 1999 J. Neuroscience 19:4748-4754
GTPase activating protein GAP NP_037409 not mapped Gschwendt et al., 1993 BBRC 194:571-576
histone H1 (in vitro)      
HMGA1 = high mobility group AT-hook 1 AAH67083 Ser44, Ser64 Xiao et al., 2000 J. Neurochem. 74:392-399
hnRNP A1 heterogenous nuclear ribonucleo protein A1 NP_002127 Ser95, Ser192, Ser199 Idriss et al., 1994 Biochemistry 33:11382-11390
IKK beta IkB kinase beta NP_001547 not fully mapped Lalena et al., 1999, MCB 19:2180-2188
IRAP Insulin Responsive Aminopeptidase Q9UIQ6 Ser80, Ser91 Ryu et al., 2002 Arch. Biochem. Biophys. 403:71-82
IRS-1 Insulin Receptor Substrate-1 NP_005535 Ser1101 Ravichandran et al., 2001 JBC 276:3543-3549 ; Li et al., 2004 JBC 279(44):45304-45307
Lamin B NP_005564 Ser395, Ser405 Goss et al., 1994 JBC 269:19074-19080
LC1 L-type calcium channel CAA12175 not mapped Hell et al., 1993 JBC 268:19451-19457
LC2 L-type calcium channel CAA12175 not mapped Hell et al., 1993 JBC 268:19451-19457
LGL lethal giant larvae homolog 1 NP_004131 Ser654, Ser658, Ser662, Ser670, Ser673 Plant et al., 2003 Nat. Cell Biol. 5:301-308
LSP1 lymphocyte specific protein NP_002330 not mapped Matsumoto et al., 1995 J. Biochem. Tokyo, 117:222-229
MARCKs NP_002347 Ser159, Ser167, Ser172 Heemskerk et al., 1993 BBRC190:236-241
Moesin = Membrane-organizing extension spike protein P26038 Thr558 Pietromonaco et al., 1998 JBC 273:7594-7603
MSH2 P43246 not mapped Hernandez-Pigeon et al., 2005 J. Mol. Biol. 348:63-74
MSH6 P52701 not mapped Hernandez-Pigeon et al., 2005 J. Mol. Biol. 348:63-74
myosin heavy chain non muscle macrophage NP_079005 not mapped Murakami et al., 1994 JBC 269:16082-16090
myosin regulatory light chain 2 smooth muscle P24844 Ser1, Ser2, Thr9 Ikebe M. et al., 1987 JBC 262:9569-9573
Neuron specific protein B50, GAP43, Neuromodulin P17677 Ser41 De Graan et al., 1988 J Recept Res. 8:345-361, Nielander et al., 1990 J. Neurochem. 55:1442-1445
NFAT1 = nuclear factor of activated T-cells Q13469 not mapped San-Antonio et al., 2002 JBC 277:27073-27080
NMDA receptor Q05586 Ser890, Ser896 Tingley et al., 1997 JBC 272:5157-5166
P protein of human parainfluenza virus type 3 (HPIV3) BAA00031 not mapped De et al., 1995 PNAS USA 92:5204-5208
p21WAF = CIP1A NP-000380 not mapped Kashiwagi et al., 2000 Oncogene 19:6334-6341
p300 CBP= E1A BP = p300 histone acetyltransferase/transcription coactivator Q09472 Ser89 Yuan et al., 2002 Biochim Biophys Acta. 1592:205-211
p47phox = Neutrophil cytosol factor 1 P14598 Ser303, Ser304, Ser315 and more Dang et al., 2001 J. Immunol.166:1206-1213
p70S6K1 beta Q9UBS0 Ser473 Valovka et al., 2003 MCB 23:852-863
p73beta (tumor suppressor) AAK81885 Ser289 Ren et al., 2002 JBC 277:33758-33765
PAR-1 = MARK3 = cTAK1 = STK10 P27448 Thr587 Hurov et al., 2004 Curr. Biol. 14:736-741
PAR-1a = MARK2 = isoform a NP_059672 Thr562 Hurov et al., 2004 Curr. Biol. 14:736-741
PAR-1b = MARK2 isoform b = EMK1 Q7KZI7 Thr595 Hurov et al., 2004 Curr. Biol. 14:736-741
PAR-3 = Partitioning-defective homologue 3= atypical PKC interacting protein ASIP Q8TEW0 Ser827 Nagai-Tamai et al., 2002 Genes Cells 7:1161-1171
P-glycoprotein 1, Multidrug Resistance 1, CD243 antigen P08183 not mapped Chambers et al., 1990 JBC 265:7679-7686
Phospholipid Scramblase = PLSCR1 NP_066928 Thr161 Frasch et al., 2000 JBC 275:23065-23073 ; Bailey et al., 2005 BBA 1733:199-209
Phosphoprotein P rabies virus P15198 Ser162, Ser210, Ser271 Gupta et al., 2000 J. Virol. 74:91-98
PICK1 Q9NRD5 not mapped Staudinger et al., 1995 JCB:128:263-271
PKD = PKC mu NP_002733 Ser738, Ser742 Brandlin et al., 2002 JBC 277:6490-6496
PLA2, phospholipase A2   not mapped Nemenoff et al., 1993 JBC 268:1960-1964
PMCA 2a plasma membrane Ca++ pump 2a   not mapped Enyedi et al., 1997 JBC 272:27525-27528
PMCA 3a plasma membrane Ca++ pump 3a   not mapped Enyedi et al., 1997 JBC 272:27525-27528
PMCA 4b plasma membrane Ca++ pump 4b NP_001675 not mapped Wang et al., 1991 JBC 266:9078-9085
Presenilin-1 = PS-1 (only after cleavage) P49768 c-terminal fragment Walter et al., 1997 PNAS USA 94:5349-5354
Profilin = PFN NP_005013 not mapped Vemuri and Singh 2001 Cell Signal. 13:433-439
Protein phosphatase inhibitor 1 = IPP1 Q13522 Ser67 Braz et al., 2004 Nature Med. 10:248-254
Prothrombin, Coagulation factor II P00734 not mapped Abe et al., 1991 BBRC 176:1123-1129
PTP alpha = receptor protein tyrosine alpha NP_543030 Ser184, Ser204 Tracy et al., 1995 JBC 270:10587-10594 ; Brandt et al., 2003 JBC 278:34073-34078
Raf-1 P04049 Ser259, Ser499 Kolch et al., 1993, Nature 364:249-252
RasGRP3 Q8IV61 Thr133 Teixeira et al., 2003 Blood 102:1414-1420 ; Aiba et al., 2004 PNAS USA 101:16612-7
RelA = NF-kappa-B p65 subunit Q04206 Ser311 Leitges et al., 2001 Mol Cell. 8:771-780 ; Duran et al., 2003 EMBO J. 22:3910-3918
RGS2 = Regulator of G protein 2 NP_002914 not mapped Cunningham et al., 2000 JBC 276:5438-5444
Rhodopsin NP_000530 not mapped Sagi-Eisenberg et al., 1989 Cell Signal. 1:519-531
RKIP = Raf kinase inhibitor protein = Phosphatidylethanolamine-binding protein (PEBP) P30086 Ser153 Lorenz et al., 2003 Nature 426::574-579
Smad 2 = Sma and Mad related protein 2 NP_005892 Ser47, Ser110 Yakymovych et al., 2001 FASEB J. 15:553-555
Smad3 NP_005893 Ser37, Ser70 Yakymovych et al., 2001 FASEB J. 15:553-555
SP-1 transcription factor NP_612482 Zinc finger region Pal et al., 1998 JBC 273:26277-26280
SRBC sdr-related gene product that binds to c-kinase NP_659477 not mapped Izumi et al., 1997 JBC272:7381-7389
Stat3 = signal transducer and activator of transcription 3 NP_644805 Ser727 Jain et al., 1999 JBC 274:24392-24400
TNF receptor = TNF-R1 = CD120a P19438 not mapped Kilpatrick et al., 2000 Am. J. Physiol. Cell Physiol. 279: C2011–C2018
Transducin alpha GTP binding protein = TD P11488 not mapped Sagi-Eisenberg et al., 1989 Cell Signal. 1:519-531
Tyrosinase NP_000363 Ser505, Ser509 Park et al., 1999, JBC 274:16470-16478
UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase Q9Y223 not mapped Horstkorte et al., 2000 FEBS Lett. 470:315-318
VASP = Vasodilator-stimulated phosphoprotein NP_003361 Ser157 Chitaley et al., 2004 FEBS Lett. 556:211-215

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