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Substrates

 
Substrates of SAPK2a = p38alpha Map kinase
Substrates Acc. No Sites Reference
ATF-2 NP_001871 Thr 69 and Thr 71 van Dam et al., 1995 EMBO J. 14:1798-811
Cdc25B NP_004349   Bulavin et al., 2001 Nature 411:102-107
Cdc25C NP_073720   Bulavin et al., 2001 Nature 411:102-107
CHOP-1, GADD153 P35638

Ser78, Ser81

Wang et al., 1996 Science 272:1347-9
Cyclin D3 NP_001751 Thr283 Casanovas et al., 2004 Oncogene 23:7537-44
MAPKAP K2 P49137 Thr222, Ser272, Thr334

Rouse et al., 1994, Cell 78, 1024-1034
Ben Levy et al., 1995, EMBO J. 14, 5920-5930
MAPKAP K3 NP_004626 Thr201, Ser251, Thr313 McLaughlin et al., 1996, JBC 271, 8488-8492
MAPKAP K5, PRAK NP_003659 Thr182

New et al., 1998, EMBO J. 17, 3372-3384
MSK1 AAC31171 Ser 360, Thr 581 Deak et al., 1998 EMBO J. 17;:4426-41
MITF   Ser 307 Mansky et al., 2002, JBC 277, 11077-11083
MNK1 Q9BUB5 Thr221 Waskiewicz et al., 1997 EMBO J. 16:1909-20
MNK2 Q8CDB0 Thr 197, Thr 202 and Thr 332 Waskiewicz et al., 1997 EMBO J. 16:1909-20
C/EBP beta   Thr45  
Cyclin D1 AAH14078 Thr 286 Casanovas et al., 2000 JBC 275:35091–7
MEF2A Q02078 Thr312, Thr319 Zhao et al., 1999 Mol Cell Biol. 19:21-30
MEF2C NP_002388 Thr293, Thr300, Ser 387?

Han et al., 1997 Nature 386:296-9
Zhao et al., 1999 Mol Cell Biol. 19:21-30
PHAS1   T35, T44, S63, T68  
PLA2 (Ca 21 -sensitive 85-kDa cytosolic phospholipase A2)
 P47712 Ser 505 Kramer et al., 1996 JBC 271:27723–9
PPARa (peroxisome
proliferator-activated receptor)		 NP_116033 Ser6, Ser12, Ser21 Barger et al., 2001 JBC 276:44495–501
p47phox   Ser345, Ser348 Manke et al., 2005 Mol Cell 17:37-48
p53 NP_000537 Ser 33

Sanchez-Prieto et al., 2000 Cancer Res. 60:2464-72
RSK-B NP_003933 Ser 343, Thr 568 and Thr 687 Pierrat et al., 1998 JBC 273:29661-71
Sap-1a P28324 Ser381, Ser387 Jahnknecht & Hunter, EMBO J.16:1620-7
STAT1 NP_009330 Ser727 Kovarik et al., 1999 Proc Natl Acad Sci U S A. 96:13956-61
TAB1 (TAK1 binding protein) also isoforms 2 & 3 AAC12660 Ser 423 and Thr 431

Cheung et al., 2003 EMBO J. 22:5793-805
Tau AAC04279 Thr 181, Ser 202, Thr 205, Ser 396 and Ser 422 Reynolds et al., 1997 J Neurochem. 69:191-8

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